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Sleep, Travel and Smoking
 
Sleeping difficulties

Temporary sleeplessness can have a significant impact on our health and general wellbeing. Sleep has a 'restorative' effect on the human body and mind. It is not just a matter of duration, the quality of sleep is also important. Rapid eye movement (REM) sleep - this is the time we dream - is essential and must be balanced. Lack of it produces an unsatisfying sleep which leaves you feeling tired. Excess alcohol can reduce the amount of REM sleep and so should be avoided.

Sleeplessness can be caused by stress, problems or jet lag. A number or bodily functions including body temperature regulation, hormone secretion and sleep operate rhythmically following an individual's 'body clock'. The hormone, melatonin, secreted during the hours of darkness, serves as the body's night-time indicator, helping to regulate these rhythmic functions. The body-clock rhythm, melatonin secretion, body temperature and sleep are all interdependent. Any change in one factor will upset the overall balance.; thus shift work and travel across time zones de-synchronize the body clock, so disrupting normal sleep.

 
Condition Insomnia
Symptoms Difficulty in falling asleep; frequent awakenings; early awakenings
OTC Treatment - Sedatives e.g. antihistamines such as diphenhydramine and promethazine
NB: Antihistamines such as diphenhydramine should be avoided by people with conditions such as asthma, narrow angle glaucoma, prostatic hypertrophy (enlarged prostate), bladder obstruction, pyloroduodenal obstruction (blockage of the gut) or stenosing peptic ulcer (stomach or duodenal ulcers).
Other self-help

A number of simple self-help measures can help you to manage your insomnia:
- Give yourself a  relaxing bedtime routine (bath, milky drink)
- Stop smoking – or at least cut down
- Find a way to reduce your stress levels e.g. take a yoga class
- Avoiding daytime sleeping
- Avoiding exercise just before bedtime (but do some regular exercise)
- Avoiding drinking tea, coffee and fizzy drinks from early evening onwards
- Not working or watching television in bed
- Making sure your bed and bedroom is comfortable
- Not going to bed unless you feel tired.

Some herbal remedies are also regarded as useful for insomnia due to their calming sedative effects (see www.hsis.org).

Other information The causes of  temporary insomnia are:
- Stress/anxiety
- Illness e.g. depression, thyroid problems, menopausal symptoms, night-time cough, pain
- Lifestyle e.g. shift work; jet-lag; over-tiredness; in-take of stimulants, including caffeine, alcohol and nicotine; exercising close to bedtime; daytime sleeping; an uncomfortable, noisy or unfamiliar environment. After travel across time zones, or changes in working hours, it can take the body clock a few days to two weeks to become resynchronised. A number of OTC sleep-aid products i.e. those with promethazine hydrochloride or diphenhydramine as their active ingredient, are sedative antihistamines. These OTC drugs are also:
- Available as tablets or liquid- Intended for short-term use in the relief of temporary sleeplessness
- For adult use only (not for use in children under 16 years)
- Generally well tolerated
- Not to be taken with other sedatives, alcohol or certain prescription drugs for depression
- Non-habit forming
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Travel (motion) sickness

Travel sickness affects many people of all ages, but younger people seem to be more prone to its effects. It affects many people of varying degrees when they are subject to swaying or pitching movements. Sufferers can experience motion sickness in cars, on planes and on ships - especially when conditions are undulating or rough!

The main organs of balance or equilibrium are located in the inner ear. Each consists of three fluid-filled canals, which contain tiny hairs. These respond to the changes in the position of the head and transmit this information to the brain where it is processed. Motion sickness occurs when there is excessive stimulation of the semi-circular canals; as a result the brain detects major changes in the position of the head, yet sensory input from the eyes seems out of step. This confusion in sensations is thought to cause motion sickness.

The eyes and certain sensory cells in the skin and internal tissues also help to maintain normal balance by transmitting information to the brain on the body's position relative to its external environment. Together, sensory input from the semi-circular canals, eyes and other sites control the body's balance.

 
Condition Travel (Motion) Sickness
Symptoms

Mild:
- Can be slight nausea
Severe:
- Vomiting
- Dizziness
- Sweating
- Unsteady gait
- Loss of balance
- Loss of co-ordination

OTC Treatment

Two main groups of OTC drugs can be used to treat motion sickness:
Anticholinergics: These are thought to prevent motion sickness by controlling vomiting. These drugs can cause dry mouth, blurred vision, dizziness, constipation and urinary retention. They are unsuitable for use in people who have glaucoma, urinary problems, high blood pressure or heart disease.
Antihistamines: Many antihistamines have anti-nausea properties and proven effectiveness in the treatment of motion sickness and the dizziness/nausea associated with disorders of equilibrium.
Antihistamines available OTC for travel sickness include promethazine, dimenhydrinate, meclozine and cinnarizine.
These antihistamines can make you drowsy. Children can take these drugs at half the adult dose or less.

Other self-help

The following measures can help reduce symptoms:
Road travel: ride in the centre of a moving vehicle; look out of a window (especially children); avoid reading and open the window for fresh air
Air travel: sit over the wings of an aeroplane. Avoid alcohol.
Sea travel: ride in the centre of the vessel, fixing the eyes on the horizon.
‘Travel bands’ are a non-drug option that can be worn around the wrist and relieve pressure by use of acupressure.
NB: Anyone prone to motion sickness should try to take a remedy before leaving home as some are ineffective once an attack has begun.

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Smoking cessation

The immediate and long-term damaging effects of smoking are generally well recognised. Some 14 million people in the UK smoke; around 10 million of these would like to stop and around 4 million are attempting to stop at any given time.

Cigarettes are the most popular form of smoking in the UK. Laboratory and clinical research has shown that cigarettes contain about 4,000 chemicals, some of which are highly toxic. Nicotine, a major constituent of tobacco smoke, is highly addictive and largely responsible for the pleasurable effects of smoking as it has mood enhancing and anxiety relieving effects. It takes 7 seconds for nicotine to reach the brain after inhalation.

Medically, nicotine is an addictive drug. Physical dependence occurs because the body develops a tolerance to nicotine, so that increasing amounts are needed to produce the same 'pleasurable' effects. The smoker must inhale more deeply or smoke more cigarettes to get he desired effect. Psychological dependence on tobacco occurs because smoking becomes a habit that is pleasurable and sociable.

Smoking is viewed by the health profession as the most preventable cause of death in the modern world. More than 100,000 people die each year in the UK from smoking-related diseases.

Many pharmacies offer non-judgemental support as part of a smoking-cessation programme.

 
Condition Smoking Cessation
Symptoms Symptoms of  nicotine withdrawal reach a peak in the first 1-2 days after stopping smoking but generally lessen after 3-4 weeks. These symptoms include depression, irritability, frustration, anger, anxiety, restlessness, insomnia, difficulty concentrating, decreased heart rate and an increased appetite.
OTC Treatment

Nicotine Replacement Therapy: Several OTC nicotine-replacement products are available in the form of:
- Chewing gums
- Lozenges
- Sublingual tablets
- Transdermal patches
- Sprays and inhalers.
All these products treat nicotine dependence as a step to help you stop smoking. When you use these products properly you’ll gradually reduce the dose of nicotine you have over several weeks, help easing withdrawal symptoms and ultimately breaking the physical nicotine dependence.
It is usual for a treatment course of 3 months to be recommended and it’s important not to smoke any cigarettes during this time.
Nicotine replacement is not recommended for pregnant or breastfeeding women and should not be given to children. Those with cardiovascular disease should consult a GP.
Side effects of nicotine therapy include exacerbation of the symptoms of peptic ulceration and gastritis.
Nicotine Transdermal patches: These are small, self-adhesive patches that deliver nicotine into the bloodstream through the skin, over the course of several hours. Depending on the type used, a fresh patch is applied daily  for 16 or 24 hours over a period of 3 months.
The patches come in different strengths and  nicotine intake is reduced by progressively switching to lower-strength patches over a treatment period.
Although the patches produce lower levels of nicotine than a cigarette, blood levels are sufficient to overcome cravings and withdrawal symptoms such as restlessness and anxiety.
Local irritation can occur where the patch is on the skin, so try to apply the patch to different areas of skin.
Nicotine Gum: Nicotine is released from the gum as it is chewed; it is absorbed through the lining of the mouth. Nicotine gum should be chewed correctly for maximum effectiveness and fewer side effects. It should be chewed when there is an urge to smoke. Once a strong taste is experienced, the gum should be placed between the gum and cheek until the taste has gone. The gum should be chewed again until the taste subsides. This is repeated over a 30-minute period.Nicotine gum is available in 2mg and 4mg strengths. The stronger gum is recommended for those who smoke more than 20 cigarettes per day and are therefore more highly dependent on nicotine.
Adverse effects associated with chewing gum include: jaw pain; tooth trouble; throat irritation and mouth ulcers.
Nicotine lozenges and sublingual tablets: Oral nicotine replacement therapy is now also available as a lozenge (containing 1mg of nicotine) and sublingual tablet (containing 2mg nicotine).
Lozenges should be sucked every 1-2 hours when you feel the urge to smoke, usually. 8-12 lozenges per day. The recommended dose for sublingual tablets is one tablet per hour (8-12 tablets per day) for those smoking less than 20 cigarettes a day, and 2 tablets per hour (16-24 tablets per day) for those smoking more than 20 cigarettes a day.
Adverse effects include tooth trouble, throat irritation and mouth ulcers.
Nicotine Inhaler: A nicotine inhaler comprises a mouthpiece containing a replaceable cartridge with 10mg of nicotine. This type of cessation therapy helps to overcome the behavioural dependence on cigarettes and, in particular, the habitual hand-to-mouth activity. This product is therefore most suitable for people who have a high behavioural dependenceAnd who smoke less than 20 cigarettes a day.
The nicotine from the inhalation device is absorbed through the lining of the mouth. An inhaler produces approximately one-third of the nicotine levels achieved from cigarette smoking, which is adequate to suppress withdrawal symptoms. The nicotine vapour is inhaled by shallow puffing or deeply inhaling, but the amount absorbed is similar whichever technique is used.
To make sure enough nicotine is inhaled to depress the withdrawal symptoms, 6-12 cartridges should be used each day for the first 8 weeks. The number of cartridges is then halved over the next two weeks and then halved daily until none are used by week 12.
Side effects diminish with use and include cough, hiccups, sinusitis, irritation in the mouth and a sore throat.

Other self-help

There are several steps you can take to help yourself control psychological dependence on – and physical craving for – cigarettes:
Take one day at a time: Stopping smoking is hard. Aim to get through the day.
Keep a positive attitude: Remain determined and remind yourself why you want to stop smoking
Keep busy: Physical activity will take your mind off the craving
Change Routine: Do something you don’t normally do; something you won’t associate with smoking.
Avoid temptation: Don’t allow yourself to get into difficult situations where you might be tempted to smoke; just one cigarette can upset all your efforts
Eat the right food: If you feel more hungry than usual try to eat more raw fruit and vegetables and avoid snacking on high-calorie foods.
Ask for help if you need it: Visit your pharmacy or GP – or use a help-line for extra support. Join a support group, or talk to a friend who has succeeded.
Get a buddy: Stopping along with someone else can help provide motivation. Tell your friends you have stopped as well as they will try to help you.

Other information

At low doses nicotine acts like a stimulant, can ‘sharpen’ the senses and improve the ability to concentrate. However, higher doses can cause a calming and soothing effect. Habitual smokers can readily adjust their nicotine dose to achieve the desired effect: e.g. when anxious the smoker will draw heavily o a cigarette to get the higher dose needed to feel calmer.
In addition to its central affects on the brain, nicotine has other effects on the body:
- Relaxation of the gut
- Relaxation of skeletal muscles, sometimes causing tremor
- Increased secretion of certain hormones
- Increased heart rate and raised blood pressure
- Reduction in blood-flow, causing poor circulation.
Regular smokers become physically and psychologically dependent on nicotine. Physical dependence arises because the body develops a tolerance to nicotine so that increasing amounts are needed to produce the same pleasurable effects. The smoker must inhale must inhale more deeply, or smoke more cigarettes to get the desired effect. Psychological dependence on tobacco occurs because smoking becomes a habit and it becomes sociable and pleasurable.
Cigarette smoke: the ingredients Dangerous ingredients – apart from nicotine – of cigarette smoke include:
Carbon monoxide: prevents oxygen from binding to red blood cells, damages blood cells
Hydrogen cyanide: affects respiration and other body functions, damages blood vessels
Formaldehyde: irritant to membranes, is carcinogenic
Hydrocarbons and nitrosamines: carcinogenic, particularly in lung tissue
Amines: carcinogenic (casually associated with bladder cancer in men)
- Heavy metals (arsenic, cadmium, lead, nickel) are all poisons.
Health effects of smoking
- Increases risk of certain types of cancer (lung, mouth, throat, oesophagus, stomach, bladder, kidney, pancreas and cervix)
- The risk of dying from lung cancer is 22 times higher for male smokers and 12 times higher for female smokers – compared with non-smokers
- The risk of developing lung cancer increases with the number of cigarettes smoked daily
- Smoking causes a 5-fold increase in the risk of dying from lung problems such as chronic bronchitis or emphysema
- Smoking causes a 2-4-fold increase in risk of death from diseases of the heart and coronary arteries; more smokers die from coronary heart disease than from lung cancer.
- The risk of stroke is increased by about 50% in 20-a-day smokers
- Smokers are more likely to get duodenal ulcers – and these are more likely to take longer than normal to heal
- Can cause premature and underweight babies to be born to pregnant women who smoke. Can also cause miscarriage and foetal malformation.
THE GOOD NEWS IS THAT STUDIES IN EX-SMOKERS SHOW THAT THEIR RISK OF DYING FROM SMOKING-RELATED DISEASE DECREASES WITH EACH YEAR OF ABSTINENCE:
- After 3 years of not smoking, the risk of having a heart attack is reduced to that of a life-long non-smoker
- After 10 cigarette-free years the risk of lung-cancer is halved
- 15 years after stopping smoking, the risk of developing almost any smoking-related disease is reduced to little more than that of a life-long non-smoker

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Loss of appetite
 
Condition Loss of appetite
Symptoms A lack of feeling hungry. NOTE - If a person is losing weight for no apparent  reason then they should seek medical advice.
OTC Treatment

Vitamin and mineral supplements sold individually or as tonics.
OTC tonics contain various combinations of the following ingredients:
Caffeine: included to promote well-being; it increases cardiovascular function, stimulates the central nervous system, stimulates the action of the heart and lungs, promotes urine formation and can aid digestion.
Alcohol: Useful in small amounts to stimulate gastric juices and stimulate appetite
Vitamins: A, B1 (thiamine), B3 (niacin), D/D2
Minerals: including calcium/manganese/potassium/sodium glycerophosphate, copper sulphate, ferric ammonium citrate, manganese sulphate monohydrate, iron.
Some OTC tonics are not suitable for use in children, while others can be recommended for children. Tonics containing alcohol should not be used in combination with other central nervous system depressants. Caffeine-containing products should not be used where caffeine-sensitivity is suspected. Side effects of caffeine include nausea, headache and insomnia.

Other information

Illness or surgical operations can often leave you feeling in need of a boost to help you recover and gain strength.
It can be difficult to eat healthy, nutritious food when you have little appetite. And even if you do feel like eating, the recovery process can be helped by supplementing the diet with additional vitamins and minerals.
Vitamins and minerals are included in tonics because:
- Vitamins enhance the metabolism of proteins, carbohydrates and fats; without these vitamins the breakdown and assimilation of foods couldn’t occur. Certain vitamins participate in the formation of blood cells, hormones and nervous system chemicals.
- Minerals help the structural composition of hard and soft body tissues; they also participate in the action of enzyme systems, the contraction of muscles, nerve reactions and blood clotting.
Most people will get enough vitamins if they eat a health diet. See www.hsis.org for more information on supplements and who can benefit from taking them.

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Stimulants and Tonics
These are used as pick-me-ups or appetite promoters in those who are ill or convalescing. They can help rebuild strength and aid a speedy recovery. Stimulants contain some similar ingredients to tonics but are more specifically aimed at relieving fatigue and improving alertness.
 
Condition Fatigue and listlessness
Symptoms Feeling more tired than usual; lacking energy
OTC Treatment

Stimulants contain the following ingredients in various combinations:
Caffeine:  promotes well being; increases cardiovascular function, stimulates the central nervous system, stimulates the action of the heart and lungs, promotes urine formation and can aid digestion. This should not be used long term not least because you can build up a dependence and tolerance to caffeine.
Vitamins: B1 (thiamine), B2, and B3 (niacin) enhance the metabolism of proteins, carbohydrates and fats. Most people will get enough vitamins if they eat a healthy diet.
Glucose monohydrate: Boosts energy levels.
NB: Stimulants are not to be used by children.

Other information

Any stimulant drug acts to excite the central nervous system, increase alertness and lower fatigue. Stimulants can be recommended to help overcome feelings of tiredness resulting from illness, overwork, stress or where you simply feel the need for a boost of energy.
Caffeine, the most commonly used stimulant, is present naturally in coffee, tea and some fizzy drinks. Anyone taking an OTC stimulant shouldn’t drink excess amounts of these as high doses of caffeine can induce tremors and severe agitation.

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MedicineChestOnline.com is a directory of medicines and food supplements that are available 'over the counter' (OTC) from your pharmacist. The links below will take you to pages detailing products which may help treat or relieve the following symptoms:

 
NHS Direct - The gateway to health information on the internet.
Contains a list of information on health, including features, healthy living, healthcare guide, conditions and treatments and frequently asked questions.
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